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ZIRC
ZFIN ID: ZDB-GENE-140711-5
Gene Name: inverted formin, FH2 and WH2 domain containing
Gene Symbol: inf2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Involved in several processes, including glomerular filtration; glomerular visceral epithelial cell development; and slit diaphragm assembly. Used to study glomerulosclerosis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Is expressed in several structures, including blood vessel; digestive system; eye; pronephros; and somite. Orthologous to human INF2 (inverted formin, FH2 and WH2 domain containing).
Genome Resources: Alliance (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-inf2 N/A 1
MO2-inf2 N/A 2
DISEASE ASSOCIATED WITH inf2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease dominant intermediate E Alliance Charcot-Marie-Tooth disease, dominant intermediate E 614455
focal segmental glomerulosclerosis 5 Alliance Glomerulosclerosis, focal segmental, 5 613237
DISEASE ASSOCIATED WITH inf2 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
glomerulosclerosis WT + MO1-inf2 standard conditions Sun et al., 2014
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of Rho protein signal transduction (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-inf2 polyclonal Rabbit IHC Sigma-Aldrich
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM inf2 No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA GenBank:EV558226 (1) 534 bp
ORTHOLOGY for inf2 ( Chr: 17 )
CITATIONS (8)