ZFIN ID: ZDB-GENE-131113-1
Gene Name: potassium voltage-gated channel, shaker-related subfamily, member 2a
Gene Symbol: kcna2a    Nomenclature History

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Previous Name: Kv1.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have voltage-gated potassium channel activity. Involved in sleep. Predicted to localize to the voltage-gated potassium channel complex. Is expressed in head.
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000002241 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20814 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44645 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kcna2a N/A 1
    PHENOTYPE
    Data: 2 figures from Srdanovic et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH kcna2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 32 Alliance Epileptic encephalopathy, early infantile, 32 616366
    DISEASE ASSOCIATED WITH kcna2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sleep (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000210 BTB/POZ domain
    Domain IPR003131 Potassium channel tetramerisation-type BTB domain
    Domain IPR005821 Ion transport domain
    Family IPR003968 Potassium channel, voltage dependent, Kv
    Family IPR003972 Potassium channel, voltage dependent, Kv1
    Family IPR004049 Potassium channel, voltage dependent, Kv1.2
    Family IPR028325 Voltage-gated potassium channel
    Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
    Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-kcna2 polyclonal Rabbit IHC Novus Biologicals, LLC
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kcna2a No data available
    MARKER RELATIONSHIPS
    kcna2a Contained in: [BAC] CH73-59H16
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:FP017253 (1) 122967 nt
    Select Tool
    Polypeptide UniProtKB:E7F8M2 (1) 493 aa
    ORTHOLOGY for kcna2a ( Chr: 6 )
    CITATIONS (13)