ZFIN ID: ZDB-GENE-121214-31
Gene Name: heat shock protein family A (Hsp70) member 8b
Gene Symbol: hspa8b    Nomenclature History

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Previous Name: si:dkey-4p15.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to localize to cytosol; nucleus; and plasma membrane. Is expressed in somite. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8).
Genome Resources: Alliance (1),  Gene:562935 (1),  Ensembl(GRCz11):ENSDARG00000037403 (2)
GENE EXPRESSION
All Expression Data: Fig. S4 from Boyle Anderson et al., 2018
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Segmentation:20-25 somites (19.0h-22.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42524 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hspa8b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hspa8b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to unfolded protein (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA si:dkey-4p15.3-201 (1)    Ensembl 2510
    si:dkey-4p15.3-202 (1)    Ensembl 634
    ncRNA si:dkey-4p15.3-003 (1)    Ensembl 734
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hspa8b No data available
    MARKER RELATIONSHIPS
    hspa8b Contained in: [BAC] DKEY-4P15 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001200012 (1) 2515 nt
    Genomic GenBank:CR626889 (1) 205513 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1R9V3 (1) 647 aa
    Sequence Information (all 7)
    ORTHOLOGY for hspa8b ( Chr: 15 )
    CITATIONS (16)