Gene
nfkb1
- ID
- ZDB-GENE-121204-3
- Name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- Symbol
- nfkb1 Nomenclature History
- Previous Names
-
- p50 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer; common variable immunodeficiency; lung non-small cell carcinoma; melanoma; and prostate cancer. Orthologous to several human genes including BICDL1 (BICD family like cargo adaptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Immunodeficiency, common variable, 12 | 616576 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR030492 | Rel homology domain, conserved site |
Domain | IPR002909 | IPT domain |
Domain | IPR011539 | Rel homology domain, DNA-binding domain |
Domain | IPR032397 | Rel homology dimerisation domain |
Domain | IPR033926 | NFkappaB IPT domain |
Family | IPR000451 | NF-kappa-B/Dorsal |
Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
Homologous_superfamily | IPR037059 | Rel homology domain (RHD), DNA-binding domain superfamily |
Domain Details Per Protein
Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | NF-kappa-B/Dorsal | NFkappaB IPT domain | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, conserved site | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9QGX8
|
539 | ||||||||||
UniProtKB:A0A8M9QPM1
|
534 | ||||||||||
UniProtKB:A0A0R4IN79
|
540 |
Interactions and Pathways
Plasmids
No data available