Gene
adamts17
- ID
- ZDB-GENE-121030-7
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 17
- Symbol
- adamts17 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif 17).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Brunet et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Weill-Marchesani syndrome | Alliance | Weill-Marchesani 4 syndrome, recessive | 613195 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR002870 | Peptidase M12B, propeptide |
| Domain | IPR006586 | ADAM, cysteine-rich domain |
| Domain | IPR010294 | ADAMTS/ADAMTS-like, Spacer 1 |
| Domain | IPR010909 | PLAC |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Domain | IPR041645 | ADAMTS, cysteine-rich domain 2 |
| Domain | IPR045371 | ADAMTS/ADAMTS-like, cysteine-rich domain 3 |
| Domain | IPR056270 | A disintegrin and metalloproteinase with thrombospondin motifs 17/19, C-terminal helical domain |
| Family | IPR013273 | ADAMTS/ADAMTS-like |
| Family | IPR050439 | ADAMTS and ADAMTS-like |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAM, cysteine-rich domain | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | A disintegrin and metalloproteinase with thrombospondin motifs 17/19, C-terminal helical domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QHG7 | InterPro | 1134 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamts17-201
(1)
|
Ensembl | 3,150 nt | ||
| mRNA |
adamts17-202
(1)
|
Ensembl | 3,069 nt |
Interactions and Pathways
No data available
Plasmids
No data available