Gene
adamts17
- ID
- ZDB-GENE-121030-7
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 17
- Symbol
- adamts17 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity and nucleic acid binding activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Orthologous to human ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif 17).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Brunet et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Weill-Marchesani syndrome | Alliance | Weill-Marchesani 4 syndrome, recessive | 613195 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR002870 | Peptidase M12B, propeptide |
| Domain | IPR006586 | ADAM, cysteine-rich domain |
| Domain | IPR010909 | PLAC |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Family | IPR013273 | ADAMTS/ADAMTS-like |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Length | ADAM, cysteine-rich domain | ADAMTS/ADAMTS-like | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FGU7
|
1049 | |||||||||
|
UniProtKB:A0A140LGW0
|
1022 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
adamts17-202
(1)
|
2891 nt |
Interactions and Pathways
No data available
Plasmids
No data available