Gene

otog

ID
ZDB-GENE-120228-1
Name
otogelin
Symbol
otog Nomenclature History
Previous Names
  • einstein (1)
  • eis (1)
  • rks
  • rock solo (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have alpha-L-arabinofuranosidase activity and structural molecule activity. Involved in otolith formation and otolith tethering. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 18B. Is expressed in otic vesicle and vestibuloauditory system. Orthologous to human OTOG (otogelin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
26 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With otog Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 18B Alliance Deafness, autosomal recessive 18B 614945
Associated With otog Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR001846 von Willebrand factor, type D domain
Domain IPR002919 Trypsin Inhibitor-like, cysteine rich domain
Domain IPR006207 Cystine knot, C-terminal
Domain IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain
Domain IPR014853 Uncharacterised domain, cysteine-rich
Family IPR030105 Otogelin
Homologous_superfamily IPR029034 Cystine-knot cytokine
Homologous_superfamily IPR036084 Serine protease inhibitor-like superfamily
Homologous_superfamily IPR036195 Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily
Domain Details Per Protein
Protein Length Alpha-L-arabinofuranosidase B, arabinose-binding domain Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily Cystine knot, C-terminal Cystine-knot cytokine EGF-like domain Otogelin Serine protease inhibitor-like superfamily Trypsin Inhibitor-like, cysteine rich domain Uncharacterised domain, cysteine-rich von Willebrand factor, type D domain VWFC domain
UniProtKB:A0A1D5NS53 3120
UniProtKB:A0A1D5NSC6 255
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
AB1-otog polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations