Gene
tns1a
- ID
- ZDB-GENE-120215-32
- Name
- tensin 1a
- Symbol
- tns1a Nomenclature History
- Previous Names
-
- si:dkey-257h21.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be involved in fibroblast migration. Predicted to be located in anchoring junction. Predicted to be active in focal adhesion. Orthologous to human TNS1 (tensin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wang et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tns1a | Wang et al., 2020 | |
| CRISPR2-tns1a | Wang et al., 2020 | |
| CRISPR3-tns1a | Wang et al., 2020 | |
| CRISPR4-tns1a | Wang et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR006020 | PTB/PI domain |
| Domain | IPR013625 | Tensin/EPS8 phosphotyrosine-binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | C1-like domain superfamily | C2 domain superfamily | PH-like domain superfamily | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | PTB/PI domain | SH2 domain | SH2 domain superfamily | Tensin/EPS8 phosphotyrosine-binding domain | Tensin-like, SH2 domain | Tensin Phosphatase | Tensin phosphatase, C2 domain | Tensin, phosphotyrosine-binding domain | Tensin-type phosphatase domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B0D1 | InterPro | 1687 | |||||||||||||||
| UniProtKB:A0A8M3B3C3 | InterPro | 1688 | |||||||||||||||
| UniProtKB:A0A8M3BAB4 | InterPro | 1679 | |||||||||||||||
| UniProtKB:A0A8M9PRC6 | InterPro | 528 | |||||||||||||||
| UniProtKB:A0A8M9Q1Z4 | InterPro | 422 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-257H21 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-56B7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068221956 (1) | 7438 nt | ||
| Genomic | GenBank:BX321894 (1) | 181789 nt | ||
| Polypeptide | UniProtKB:A0A8M3B3C3 (1) | 1688 aa |
- Wang, Y., Liu, Z., Yang, G., Gao, Q., Xiao, L., Li, J., Guo, C., Troutwine, B.R., Gray, R.S., Xie, L., Zhang, H. (2020) Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes. Frontiers in cell and developmental biology. 8:582255
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Dina, C., Bouatia-Naji, N., Tucker, N., Delling, F.N., Toomer, K., Durst, R., Perrocheau, M., Fernandez-Friera, L., Solis, J., PROMESA investigators, Le Tourneau, T., Chen, M.H., Probst, V., Bosse, Y., Pibarot, P., Zelenika, D., Lathrop, M., Hercberg, S., Roussel, R., Benjamin, E.J., Bonnet, F., Lo, S.H., Dolmatova, E., Simonet, F., Lecointe, S., Kyndt, F., Redon, R., Le Marec, H., Froguel, P., Ellinor, P.T., Vasan, R.S., Bruneval, P., Markwald, R.R., Norris, R.A., Milan, D.J., Slaugenhaupt, S.A., Levine, R.A., Schott, J.J., Hagege, A.A., Mvp-France, Jeunemaitre, X., Leducq Transatlantic MITRAL Network (2015) Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nature Genetics. 47(10):1206-11
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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