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Gene

wfikkn2b

ID
ZDB-GENE-110414-1
Name
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b
Symbol
wfikkn2b Nomenclature History
Previous Names
  • wfikkn2
  • Gasp1b (1)
  • si:ch73-359p15.2
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable metalloendopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Is expressed in angioblastic mesenchymal cell; hindbrain; pectoral fin bud; and post-vent region. Orthologous to human WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Monestier et al., 2012
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wfikkn2b Human Ortholog
No data available
Associated With wfikkn2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
Domain IPR001134 Netrin domain
Domain IPR002223 Pancreatic trypsin inhibitor Kunitz domain
Domain IPR002350 Kazal domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR008197 WAP-type 'four-disulfide core' domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR018933 Netrin module, non-TIMP type
Family IPR033638 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1/2
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036058 Kazal domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Homologous_superfamily IPR036645 Elafin-like superfamily
Homologous_superfamily IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
Domain Details Per Protein
Protein Length Elafin-like superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Kazal domain Kazal domain superfamily Netrin domain Netrin module, non-TIMP type Pancreatic trypsin inhibitor Kunitz domain Pancreatic trypsin inhibitor Kunitz domain superfamily Proteinase inhibitor I2, Kunitz, conserved site Tissue inhibitor of metalloproteinases-like, OB-fold WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1/2 WAP-type 'four-disulfide core' domain
UniProtKB:J7K3J9 287
UniProtKB:E7FCX1 563
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations