Gene
hcn4l
- ID
- ZDB-GENE-110411-3
- Name
- hyperpolarization activated cyclic nucleotide-gated potassium channel 4l
- Symbol
- hcn4l Nomenclature History
- Previous Names
-
- hcn3 (1)
- si:dkeyp-74b4.2
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have cAMP binding activity; sodium channel activity; and voltage-gated potassium channel activity. Predicted to be involved in monovalent inorganic cation transport; regulation of heart rate; and transmembrane transport. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Trapani et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Fujii et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013621 | Ion transport N-terminal |
| Family | IPR003938 | Potassium channel, voltage-dependent, EAG/ELK/ERG |
| Family | IPR051413 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | Ion transport N-terminal | Potassium channel, voltage-dependent, EAG/ELK/ERG | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7TEJ3
|
1188 |
Interactions and Pathways
No data available
Plasmids
No data available