ZFIN ID: ZDB-GENE-110411-3
Gene Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 4l
Gene Symbol: hcn4l    Nomenclature History

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Previous Names: hcn3 (1), si:dkeyp-74b4.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have cAMP binding activity and voltage-gated potassium channel activity. Predicted to be involved in monovalent inorganic cation transport; regulation of heart rate; and regulation of ion transmembrane transport. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000074419 (2)
GENE EXPRESSION
All Expression Data: Fig. S3 from Trapani et al., 2011
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028702Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32539 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hcn4l HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hcn4l VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cAMP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hcn4l-202 (1)    Ensembl 2912
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hcn4l No data available
    MARKER RELATIONSHIPS
    hcn4l Contained in: [BAC] DKEYP-74B4 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:CR450817 (1) 196897 nt
    Select Tool
    Polypeptide UniProtKB:E7F3Z3 (1) 1004 aa
    Sequence Information (all 3)
    ORTHOLOGY for hcn4l ( Chr: 25 )
    CITATIONS (17)