Gene

jupb

ID
ZDB-GENE-110407-10
Name
junction plakoglobin b
Symbol
jupb Nomenclature History
Previous Names
  • si:ch73-362f1.1
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to adherens junction and catenin complex. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With jupb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
arrhythmogenic right ventricular dysplasia 12 Alliance Arrhythmogenic right ventricular dysplasia 12 611528
Naxos disease Alliance Naxos disease 601214
Associated With jupb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR013284 Beta-catenin
Family IPR030461 Junction plakoglobin
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Repeat IPR000225 Armadillo
Domain Details Per Protein
Protein Length Armadillo Armadillo-like helical Armadillo-type fold Beta-catenin Junction plakoglobin
UniProtKB:F1QUV8 726
UniProtKB:F8W4M8 667
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations