ZFIN ID: ZDB-GENE-110215-2
Gene Name: solute carrier family 4 member 1b (Diego blood group)
Gene Symbol: slc4a1b    Nomenclature History

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Previous Names: zAE1b (1), pers

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits anion:anion antiporter activity and bicarbonate transmembrane transporter activity. Involved in calcium ion import. Predicted to localize to integral component of membrane. Is expressed in ball; gill; ionocyte; and sensory system. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)).
Genome Resources: Alliance (1),  Gene:561787 (1),  Ensembl(GRCz11):ENSDARG00000024560 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010694Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la010880Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018016Tg Transgenic Insertion Unknown Unknown DNA
    la027299Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14521 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19028 Point Mutation Unknown Premature Stop ENU
    sa35221 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • w39 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-slc4a1b N/A 2
    DISEASE ASSOCIATED WITH slc4a1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spherocytosis type 4 Alliance Spherocytosis, type 4 612653
    Cryohydrocytosis 185020
    Ovalocytosis, SA type 166900
    Renal tubular acidosis, distal, AD 179800
    Renal tubular acidosis, distal, AR 611590
    [Blood group, Diego] 110500
    [Blood group, Froese] 601551
    [Blood group, Swann] 601550
    [Blood group, Waldner] 112010
    [Blood group, Wright] 112050
    [Malaria, resistance to] 611162
    DISEASE ASSOCIATED WITH slc4a1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion import (more)
    Cellular Component integral component of membrane (more)
    Molecular Function anion:anion antiporter activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc4a1b-201 (1)    Ensembl 2938
    slc4a1b-202 (1)    Ensembl 758
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-slc4a1b polyclonal Rabbit IHC, WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc4a1b No data available
    MARKER RELATIONSHIPS
    slc4a1b Contained in: [BAC] DKEY-199C16 (1) (order this), DKEYP-118B1 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001168266 (1) 2709 nt
    Genomic GenBank:BX928755 (1) 174423 nt
    Select Tool
    Polypeptide UniProtKB:D1FTM8 (1) 851 aa
    Sequence Information (all 12)
    ORTHOLOGY for slc4a1b ( Chr: 12 )
    CITATIONS (29)