ZFIN ID: ZDB-GENE-101107-1
Gene Name: formin 2a
Gene Symbol: fmn2a    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; chemical synaptic transmission; and regulation of vascular smooth muscle contraction. Predicted to localize to dendrite; integral component of plasma membrane; and synapse. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human FMN2 (formin 2).
Genome Resources: Alliance (1),  Gene:793321 (1),  Ensembl(GRCz11):ENSDARG00000023318 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42903 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42904 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fmn2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mental retardation, autosomal recessive 47 616193
    DISEASE ASSOCIATED WITH fmn2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin nucleation (more)
    Cellular Component actin filament (more)
    Molecular Function microtubule binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fmn2a-201 (1)    Ensembl 4941
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fmn2a No data available
    MARKER RELATIONSHIPS
    fmn2a Contained in: [BAC] DKEY-97L21 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001333025 (1) 4776 nt
    Genomic GenBank:CT027692 (1) 139118 nt
    Select Tool
    Polypeptide UniProtKB:X1WC43 (1) 1465 aa
    Sequence Information (all 10)
    ORTHOLOGY for fmn2a ( Chr: 17 )
    CITATIONS (16)