ZFIN ID: ZDB-GENE-101001-1
Gene Name: collagen, type IV, alpha 4
Gene Symbol: col4a4    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have extracellular matrix structural constituent. Predicted to be involved in extracellular matrix organization. Predicted to localize to collagen type IV trimer and extracellular space. Is expressed in hypodermis; lens; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal recessive Alport syndrome; benign familial hematuria; and end stage renal disease. Orthologous to human COL4A4 (collagen type IV alpha 4 chain).
Genome Resources: Alliance (1),  Gene:554270 (1),  Ensembl(GRCz11):ENSDARG00000002831 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH col4a4 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive Alport syndrome Alliance Alport syndrome 2, autosomal recessive 203780
benign familial hematuria Alliance Hematuria, familial benign 141200
DISEASE ASSOCIATED WITH col4a4 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process collagen fibril organization (more)
Cellular Component collagen trimer (more)
Molecular Function extracellular matrix structural constituent (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA col4a4-201 (1)    Ensembl 10607
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM col4a4 No data available
MARKER RELATIONSHIPS
col4a4 Contained in: [BAC] CH73-74H18 (1), DKEY-29L4 (1) (order this), DKEYP-110B2 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_009291835 (1)
Genomic GenBank:BX571880 (1) 194220 nt
Select Tool
Polypeptide UniProtKB:X1WFR7 (1) 1670 aa
Sequence Information (all 12)
ORTHOLOGY for col4a4 ( Chr: 15 )
CITATIONS (25)