| ZFIN ID: ZDB-GENE-100901-1 |
| Gene Name: | potassium voltage-gated channel, Shaw-related subfamily, member 3a | |||||||||||||
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| Gene Symbol: | kcnc3a Nomenclature History |
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| Previous Name: | kv3.3 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 3 Mapping Details/Browsers | |||||||||||||
| Description: | Exhibits voltage-gated potassium channel activity. Involved in motor neuron axon guidance. Predicted to localize to several cellular components, including dendrite membrane; neuronal cell body membrane; and voltage-gated potassium channel complex. Is expressed in Purkinje cell. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 13. Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:559096 (1), Ensembl(GRCz11):ENSDARG00000055855 (2) | |||||||||||||
| All Expression Data: | 3 figures from 3 publications |
| Wild-type Stages, Structures: | Hatching:Long-pec (48.0h-60.0h) to Larval:Day 6 (144.0h-168.0h) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| la024108Tg | Transgenic Insertion | Unknown | Unknown | DNA | |
| la024109Tg | Transgenic Insertion | Unknown | Unknown | DNA | |
| sa14531 | Point Mutation | Unknown | Premature Stop | ENU |
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| sa38398 | Point Mutation | Unknown | Premature Stop | ENU |
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| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia type 13 | Alliance | Spinocerebellar ataxia 13 | 605259 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | motor neuron axon guidance (more) |
| Cellular Component | integral component of membrane (more) |
| Molecular Function | voltage-gated potassium channel activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
kcnc3a-202
(1)
|
1929 |
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kcnc3a-203
(1)
|
2080 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
| Name | Type | Isotype | Host Organism | Assay | Source | Publications |
|---|---|---|---|---|---|---|
| Ab1-kcnc3a | Rabbit | IHC | 1 |
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM kcnc3a
No data available
MARKER RELATIONSHIPS
| kcnc3a Contained in: | [BAC] DKEY-15N1 (1) (order this), DKEY-237N7 (1) (order this) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001195240 (1) | 1980 nt |
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| Genomic | GenBank:BX324157 (1) | 272769 nt | Blast at MegaBLAST |
| Polypeptide | UniProtKB:E1AZA5 (1) | 659 aa |
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ORTHOLOGY for kcnc3a (
Chr:
3
)
CITATIONS (26)