ZFIN ID: ZDB-GENE-100901-1
Gene Name: potassium voltage-gated channel, Shaw-related subfamily, member 3a
Gene Symbol: kcnc3a    Nomenclature History

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Previous Name: kv3.3 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits voltage-gated potassium channel activity. Involved in motor neuron axon guidance. Predicted to localize to several cellular components, including the dendrite membrane; neuronal cell body membrane; and voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 13. Is expressed in Purkinje cell. Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3).
Genome Resources: Alliance (1),  Gene:559096 (1),  Ensembl(GRCz11):ENSDARG00000055855 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Larval:Day 6 (144.0h-168.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024108Tg Transgenic Insertion Unknown Unknown DNA
la024109Tg Transgenic Insertion Unknown Unknown DNA
sa14531 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38398 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kcnc3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spinocerebellar ataxia type 13 Alliance Spinocerebellar ataxia 13 605259
    DISEASE ASSOCIATED WITH kcnc3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process motor neuron axon guidance (more)
    Cellular Component integral component of membrane (more)
    Molecular Function voltage-gated potassium channel activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000210 BTB/POZ domain
    Domain IPR003131 Potassium channel tetramerisation-type BTB domain
    Domain IPR005821 Ion transport domain
    Domain IPR021105 Potassium channel, voltage dependent, Kv3, inactivation domain
    Family IPR003968 Potassium channel, voltage dependent, Kv
    Family IPR003974 Potassium channel, voltage dependent, Kv3
    Family IPR028325 Voltage-gated potassium channel
    Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
    Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kcnc3a-202 (1)    Ensembl 1929
    kcnc3a-203 (1)    Ensembl 2080
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-kcnc3a Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kcnc3a No data available
    MARKER RELATIONSHIPS
    kcnc3a Contained in: [BAC] DKEY-15N1 (1) (order this), DKEY-237N7 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001195240 (1) 1980 nt
    Genomic GenBank:BX324157 (1) 272769 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E1AZA5 (1) 659 aa
    Sequence Information (all 37)
    ORTHOLOGY for kcnc3a ( Chr: 3 )
    CITATIONS (25)