Gene

cd40lg

ID
ZDB-GENE-100727-1
Name
CD40 ligand
Symbol
cd40lg Nomenclature History
Previous Names
  • cd154 (1)
  • TNFSF5 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Exhibits CD40 receptor binding activity. Involved in positive regulation of immunoglobulin production. Localizes to external side of plasma membrane. Is expressed in gill; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).
Genome Resources
Note
None
Expression
All Expression Data
from Gong et al., 2009
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cd40lg Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
CD40 ligand deficiency Alliance Immunodeficiency, X-linked, with hyper-IgM 308230
Associated With cd40lg Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR021184 Tumour necrosis factor, conserved site
Domain IPR006052 Tumour necrosis factor domain
Homologous_superfamily IPR008983 Tumour necrosis factor-like domain superfamily
Domain Details Per Protein
Protein Length Tumour necrosis factor, conserved site Tumour necrosis factor domain Tumour necrosis factor-like domain superfamily
UniProtKB:B8YI05 260
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cd40lg IgG Rabbit
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations