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Gene

kcnh2b

ID
ZDB-GENE-100629-2
Name
potassium voltage-gated channel, subfamily H (eag-related), member 2b
Symbol
kcnh2b Nomenclature History
Previous Names
  • kcnh2l
  • zerg-24 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable voltage-gated potassium channel activity. Predicted to act upstream of or within potassium ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; gill; heart; immune system; and muscle. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Leong et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnh2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
long QT syndrome 2 Alliance Long QT syndrome 2 613688
long QT syndrome 2 Alliance {Long QT syndrome 2, acquired, susceptibility to} 613688
short QT syndrome Alliance Short QT syndrome 1 609620
Associated With kcnh2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR005821 Ion transport domain
Family IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
Family IPR003967 Potassium channel, voltage-dependent, ERG
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding-like
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Domain Details Per Protein
Protein Length Cyclic nucleotide-binding domain Cyclic nucleotide-binding-like Ion transport domain Potassium channel, voltage-dependent, EAG/ELK/ERG Potassium channel, voltage-dependent, ERG RmlC-like jelly roll fold Voltage-dependent channel domain superfamily
UniProtKB:D9IW09 756
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations