ZFIN ID: ZDB-GENE-100422-16
Gene Name: aggrecan b
Gene Symbol: acanb    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have hyaluronic acid binding activity. Involved in fin regeneration. Predicted to localize to extracellular matrix. Orthologous to human ACAN (aggrecan).
Genome Resources: Alliance (1),  Gene:559593 (1),  Ensembl(GRCz11):ENSDARG00000045799 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10866 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-acanb N/A 1
    MO2-acanb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH acanb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    osteochondritis dissecans Alliance Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 165800
    Spondyloepimetaphyseal dysplasia, aggrecan type 612813
    ?Spondyloepiphyseal dysplasia, Kimberley type 608361
    DISEASE ASSOCIATED WITH acanb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin regeneration (more)
    Cellular Component extracellular matrix (more)
    Molecular Function hyaluronic acid binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acanb-201 (1)    Ensembl 4262
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-acan monoclonal IgG1 , k Mouse IHC Thermo Fisher Scientific (Lab Vision)
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acanb No data available
    MARKER RELATIONSHIPS
    acanb Contained in: [BAC] DKEYP-19H3 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021470542 (1)
    Genomic GenBank:BX294110 (1) 176023 nt
    Select Tool
    Polypeptide UniProtKB:F8W252 (1) 1373 aa
    Sequence Information (all 10)
    ORTHOLOGY for acanb ( Chr: 25 )
    CITATIONS (20)