Gene

cxcr2

ID
ZDB-GENE-100414-1
Name
chemokine (C-X-C motif) receptor 2
Symbol
cxcr2 Nomenclature History
Previous Names
  • CXCR1bb (1)
  • si:ch73-54b5.1
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits granulocyte colony-stimulating factor binding activity. Involved in defense response to bacterium; leukocyte migration; and neutrophil activation. Predicted to localize to integral component of membrane. Is expressed in several structures, including digestive system; head; heart; intermediate cell mass of mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; human immunodeficiency virus infectious disease; pyelonephritis (multiple); and urinary tract infection. Orthologous to several human genes including CXCR2 (C-X-C motif chemokine receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Deng et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cxcr2 Human Ortholog
No data available
Associated With cxcr2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000174 CXC chemokine receptor 1/2
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Domain Details Per Protein
Protein Length CXC chemokine receptor 1/2 GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:F1Q8T9 340
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations