ZFIN ID: ZDB-GENE-100215-2
Gene Name: eukaryotic translation initiation factor 3, subunit F
Gene Symbol: eif3f    Nomenclature History

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Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to contribute to translation initiation factor activity. Involved in cranial skeletal system development. Predicted to localize to eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in female organism. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F).
Genome Resources: Alliance (1),  Gene:557270 (1),  Ensembl(GRCz11):ENSDARG00000077533 (2)
GENE EXPRESSION
All Expression Data: Table S1 from Newman et al., 2019
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zko218a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko218b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-eif3f 1
    MO1-eif3f N/A 2
    DISEASE ASSOCIATED WITH eif3f HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mental retardation, autosomal recessive 67 618295
    DISEASE ASSOCIATED WITH eif3f VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cranial skeletal system development (more)
    Cellular Component cytoplasm (more)
    Molecular Function translation initiation factor activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eif3f No data available
    MARKER RELATIONSHIPS
    eif3f Contained in: [BAC] DKEY-58J19 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001200009 (1)
    Genomic GenBank:CR854964 (1) 180969 nt
    Select Tool
    Polypeptide UniProtKB:R4GEX4 (1) 282 aa
    Sequence Information (all 9)
    ORTHOLOGY for eif3f ( Chr: 1 )
    CITATIONS (20)