ZFIN ID: ZDB-GENE-091118-1
Gene Name: colony stimulating factor 1 receptor, b
Gene Symbol: csf1rb    Nomenclature History

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Previous Name: si:ch1073-368i11.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have growth factor binding activity and macrophage colony-stimulating factor receptor activity. Predicted to be involved in hemopoiesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to CSF1-CSF1R complex; integral component of plasma membrane; and receptor complex. Is expressed in heart; microglial cell; osteoclast; and scale. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000053624 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mh108 Indel Unknown Unknown CRISPR
mh112 Small Deletion Unknown Unknown CRISPR
re01 Small Deletion Exon 3 Frameshift, Premature Stop TALEN
sa1503 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24034 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24035 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29665 Point Mutation Unknown Splice Site, Premature Stop ENU
    sa32360 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37380 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43722 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-csf1rb 1
    CRISPR2-csf1rb 1
    CRISPR3-csf1rb 1
    CRISPR4-csf1rb 1
    CRISPR5-csf1rb 1
    TALEN1-csf1rb 1
    DISEASE ASSOCIATED WITH csf1rb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Alliance Leukoencephalopathy, diffuse hereditary, with spheroids 221820
    Brain abnormalities, neurodegeneration, and dysosteosclerosis 618476
    DISEASE ASSOCIATED WITH csf1rb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of odontogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA csf1rb-202 (1)    Ensembl 2894
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM csf1rb No data available
    MARKER RELATIONSHIPS
    csf1rb Contained in: [Fosmid] CH1073-309N14 (1), CH1073-368I11 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:CU694443 (1) 35852 nt
    Select Tool
    Polypeptide UniProtKB:F1R532 (1) 964 aa
    Sequence Information (all 4)
    ORTHOLOGY for csf1rb ( Chr: 21 )
    CITATIONS (24)