ZFIN ID: ZDB-GENE-091118-1
Gene Name: colony stimulating factor 1 receptor, b
Gene Symbol: csf1rb    Nomenclature History

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Previous Name: si:ch1073-368i11.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have macrophage colony-stimulating factor receptor activity. Predicted to be involved in several processes, including hemopoiesis; positive regulation of ERK1 and ERK2 cascade; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to the CSF1-CSF1R complex; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Is expressed in microglial cell. Orthologous to human CSF1R (colony stimulating factor 1 receptor).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000053624 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Oosterhof et al., 2018
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
re01 Small Deletion Exon 3 Frameshift, Premature Stop TALEN
sa1503 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24034 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24035 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29665 Point Mutation Unknown Splice Site, Premature Stop ENU
    sa32360 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37380 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43722 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-csf1rb 1
    DISEASE ASSOCIATED WITH csf1rb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Alliance Leukoencephalopathy, diffuse hereditary, with spheroids 221820
    Brain abnormalities, neurodegeneration, and dysosteosclerosis 618476
    DISEASE ASSOCIATED WITH csf1rb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cytokine-mediated signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Family IPR030658 Macrophage colony-stimulating factor 1 receptor
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA csf1rb-202 (1)    Ensembl 2894
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM csf1rb No data available
    MARKER RELATIONSHIPS
    csf1rb Contained in: [Fosmid] CH1073-309N14 (1), CH1073-368I11 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    Genomic GenBank:CU694443 (1) 35852 bp
    Select Tool
    Polypeptide UniProtKB:F1R532 (1) 964 aa
    Sequence Information (all 4)
    ORTHOLOGY for csf1rb ( Chr: 21 )
    CITATIONS (22)