header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-091116-34
Gene Name: mannosidase, alpha, class 1B, member 1a
Gene Symbol: man1b1a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: si:ch211-181b18.1

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing and ubiquitin-dependent ERAD pathway. Predicted to localize to the endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1).
Genome Resources: Alliance (1),  Gene:562592 (1),  Ensembl(GRCz11):ENSDARG00000073792 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31055 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37256 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43604 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-man1b1a
    1
    CRISPR2-man1b1a
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH man1b1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    non-syndromic intellectual disability Alliance Mental retardation, autosomal recessive 15 614202
    DISEASE ASSOCIATED WITH man1b1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process metabolic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001382 (1)
  • InterPro:IPR012341 (1)
  • InterPro:IPR036026 (1)
  • Pfam:PF01532 (1)
  • EC:3.2.1.- (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA man1b1a-201 (1)    Ensembl 2795
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM man1b1a No data available
    MARKER RELATIONSHIPS
    man1b1a Contained in: [BAC] CH211-181B18 (1) (order this), CH211-196I2 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005161118 (1)
    Genomic GenBank:CR376852 (1) 157717 bp
    Select Tool
    Polypeptide UniProtKB:E7F4N5 (1) 682 aa
    Sequence Information (all 11)
    ORTHOLOGY for man1b1a ( Chr: 21 )
    CITATIONS (15)