Gene
slc4a4b
- ID
- ZDB-GENE-091030-1
- Name
- solute carrier family 4 member 4b
- Symbol
- slc4a4b Nomenclature History
- Previous Names
-
- nbce1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Predicted to act upstream of or within monoatomic anion transport. Predicted to be located in lateral plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including NCC ionocyte; ball; gill; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Proximal renal tubular acidosis-ocular anomaly syndrome | 604278 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011531 | Bicarbonate transporter-like, transmembrane domain |
| Domain | IPR013769 | Band 3 cytoplasmic domain |
| Family | IPR003020 | Bicarbonate transporter, eukaryotic |
| Family | IPR003024 | Sodium bicarbonate cotransporter |
| Homologous_superfamily | IPR016152 | Phosphotransferase/anion transporter |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 3 cytoplasmic domain | Bicarbonate transporter, eukaryotic | Bicarbonate transporter-like, transmembrane domain | Phosphotransferase/anion transporter | Sodium bicarbonate cotransporter |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q313 | InterPro | 918 | |||||
| UniProtKB:A0A8N7UV75 | InterPro | 1073 | |||||
| UniProtKB:A0A8M3B4G9 | InterPro | 1105 | |||||
| UniProtKB:A0A8M3AL80 | InterPro | 1122 | |||||
| UniProtKB:F1QD14 | InterPro | 1090 | |||||
| UniProtKB:A0AB32TF60 | InterPro | 904 | |||||
| UniProtKB:A0AB32TLY6 | InterPro | 856 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc4a4b-201
(1)
|
Ensembl | 3,571 nt | ||
| mRNA |
slc4a4b-202
(1)
|
Ensembl | 3,342 nt |
Interactions and Pathways
No data available
Plasmids
No data available