ZFIN ID: ZDB-GENE-091030-1
Gene Name: solute carrier family 4 member 4b
Gene Symbol: slc4a4b    Nomenclature History

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Previous Name: nbce1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport and regulation of intracellular pH. Predicted to localize to integral component of membrane. Is expressed in several structures, including NCC ionocyte; ball; gill; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4).
Genome Resources: Alliance (1),  Gene:561618 (1),  Ensembl(GRCz11):ENSDARG00000044808 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022085Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12345 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29508 Point Mutation Unknown Premature Stop ENU
    sa37225 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH slc4a4b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Renal tubular acidosis, proximal, with ocular abnormalities 604278
    DISEASE ASSOCIATED WITH slc4a4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function anion transmembrane transporter activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc4a4b-201 (1)    Ensembl 3571
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc4a4b No data available
    MARKER RELATIONSHIPS
    slc4a4b Contained in: [BAC] CH73-209E20 (1), DKEY-93M18 (order this)
    [Fosmid] CH1073-376D12 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005160996 (1) 6224 nt
    Genomic GenBank:BX530036 (1) 211643 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IUL4 (1) 1113 aa
    Sequence Information (all 23)
    ORTHOLOGY for slc4a4b ( Chr: 21 )
    CITATIONS (22)