Gene

kcnb1

ID
ZDB-GENE-090831-3
Name
potassium voltage-gated channel, Shab-related subfamily, member 1
Symbol
kcnb1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have delayed rectifier potassium channel activity. Involved in epiboly and ventricular system development. Predicted to localize to voltage-gated potassium channel complex. Is expressed in brain; central canal; otic vesicle; and ventricular system. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 26. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Shen et al., 2016
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Shen et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnb1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 26 Alliance Developmental and epileptic encephalopathy 26 616056
Associated With kcnb1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000210 BTB/POZ domain
Domain IPR003131 Potassium channel tetramerisation-type BTB domain
Domain IPR005821 Ion transport domain
Family IPR003968 Potassium channel, voltage dependent, Kv
Family IPR003973 Potassium channel, voltage dependent, Kv2
Family IPR004350 Potassium channel, voltage dependent, Kv2.1
Family IPR028325 Voltage-gated potassium channel
Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Domain Details Per Protein
Protein Length BTB/POZ domain Ion transport domain Potassium channel tetramerisation-type BTB domain Potassium channel, voltage dependent, Kv Potassium channel, voltage dependent, Kv2 Potassium channel, voltage dependent, Kv2.1 SKP1/BTB/POZ domain superfamily Voltage-dependent channel domain superfamily Voltage-gated potassium channel
UniProtKB:A0A2R8QPN6 830
UniProtKB:X1WCE7 765
UniProtKB:A0A2R8Q685 834
UniProtKB:A0A2R8Q9T9 697
UniProtKB:A0A2R8QSA8 715
UniProtKB:A0A2R8QRP8 811
UniProtKB:A0A2R8QLG2 824
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations