ZFIN ID: ZDB-GENE-090817-2
Gene Name: mesoderm posterior ab
Gene Symbol: mespab    Nomenclature History

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Previous Name: mesp2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of heart left/right asymmetry; somite rostral/caudal axis specification; and somite specification. Predicted to localize to nucleus. Is expressed in margin; mesoderm; post-vent region; and somite. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2).
Genome Resources: Alliance (1),  Gene:100006128 (1),  Ensembl(GRCz11):ENSDARG00000068761 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
kt1002 Indel Unknown Unknown TALEN
kt1030 Indel Unknown Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-mespab N/A 1
TALEN1-mespab 1
TALEN2-mespab 1
DISEASE ASSOCIATED WITH mespab HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylocostal dysostosis Alliance Spondylocostal dysostosis 2, autosomal recessive 608681
DISEASE ASSOCIATED WITH mespab VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process determination of heart left/right asymmetry (more)
Molecular Function DNA-binding transcription factor activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mespab-201 (1)    Ensembl 923
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mespab No data available
MARKER RELATIONSHIPS
mespab Contained in: [BAC] DKEY-52P2 (order this), DKEY-167J6 (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001265583 (1)
Genomic GenBank:BX572619 (1) 171026 nt
Select Tool
Polypeptide UniProtKB:A3KPB3 (1) 256 aa
Sequence Information (all 11)
ORTHOLOGY for mespab ( Chr: 25 )
CITATIONS (23)