ZFIN ID: ZDB-GENE-090812-3
Gene Name: sterol regulatory element binding transcription factor 1
Gene Symbol: srebf1    Nomenclature History

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Previous Name: SREBP1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in liver development; pancreas regeneration; and type B pancreatic cell development. Predicted to localize to nucleus. Is expressed in female organism and liver. Human ortholog(s) of this gene implicated in disease of metabolism and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1).
Genome Resources: Alliance (1),  Gene:793274 (1),  Ensembl(GRCz11):ENSDARG00000067607 (2)
GENE EXPRESSION
All Expression Data: 29 figures from 27 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18770 Point Mutation Unknown Premature Stop ENU
sa33346 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-srebf1 N/A 1
    MO2-srebf1 N/A 1
    MO3-srebf1 N/A 1
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH srebf1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH srebf1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process liver development (more)
    Cellular Component nucleus (more)
    Molecular Function protein dimerization activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM srebf1 No data available
    MARKER RELATIONSHIPS
    srebf1 Contains: [SSLP] z1191
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001105129 (1) 3504 nt
    Genomic GenBank:DQ836066 (1) 3143 nt
    Polypeptide UniProtKB:A6XLD8 (1) 1105 aa
    Sequence Information (all 13)
    ORTHOLOGY for srebf1 ( Chr: 3 )
    CITATIONS (108)