Community Action Needed: Please respond to the NIH RFI
Gene

srebf1

ID
ZDB-GENE-090812-3
Name
sterol regulatory element binding transcription factor 1
Symbol
srebf1 Nomenclature History
Previous Names
  • SREBP1 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within liver development; pancreas regeneration; and type B pancreatic cell development. Predicted to be active in nucleus. Is expressed in female organism; liver; male organism; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in disease of metabolism and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
39 figures from 36 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With srebf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ichthyosis, follicular, with atrichia and photophobia syndrome 2 619016
Mucoepithelial dysplasia, hereditary 158310
Associated With srebf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:F1RDU4 879
UniProtKB:A6XLD8 1105
UniProtKB:A6XLD9 30
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations