ZFIN ID: ZDB-GENE-090610-1
Gene Name: bone morphogenetic protein receptor, type IBb
Gene Symbol: bmpr1bb    Nomenclature History

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Previous Names: alk6b (1), zgc:172219 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have SMAD binding activity and transforming growth factor beta receptor activity, type I. Involved in BMP signaling pathway; dorsal/ventral pattern formation; and germ-line stem cell division. Predicted to localize to plasma membrane and receptor complex. Is expressed in several structures, including head; immature eye; liver; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B).
Genome Resources: Alliance (1),  Gene:100149664 (1),  Ensembl(GRCz11):ENSDARG00000102742 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sw40 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-bmpr1bb N/A 1
MO2-bmpr1bb N/A 1
MO3-bmpr1bb N/A 1
MO4-bmpr1bb N/A 1
DISEASE ASSOCIATED WITH bmpr1bb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
brachydactyly type A1D Alliance Brachydactyly, type A1, D 616849
brachydactyly type A2 Alliance Brachydactyly, type A2 112600
Acromesomelic dysplasia, Demirhan type 609441
DISEASE ASSOCIATED WITH bmpr1bb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process BMP signaling pathway (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-bmpr1bb polyclonal Rabbit IHC 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM bmpr1bb No data available
MARKER RELATIONSHIPS
bmpr1bb Encodes: [EST] fi15f06
[cDNA] MGC:172219 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001145996 (1) 1994 nt
Genomic GenBank:CU694269 (1) 101140 nt
Select Tool
Polypeptide UniProtKB:A0A0R4I9Y4 (1) 535 aa
Sequence Information (all 32)
ORTHOLOGY for bmpr1bb ( Chr: 10 )
CITATIONS (25)