ZFIN ID: ZDB-GENE-090423-1
Gene Name: sperm antigen with calponin homology and coiled-coil domains 1-like b
Gene Symbol: specc1lb    Nomenclature History

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Previous Name: cytsab

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Involved in frontonasal suture morphogenesis. Predicted to localize to filamentous actin and microtubule organizing center. Used to study orofacial cleft. Human ortholog(s) of this gene implicated in Opitz-GBBB syndrome and oblique facial clefting 1. Orthologous to human SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like).
Genome Resources: Alliance (1),  Gene:555467 (1),  Ensembl(GRCz11):ENSDARG00000042232 (2)
GENE EXPRESSION
All Expression Data: Fig. 3 from Gfrerer et al., 2014
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011406Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6665 Point Mutation Unknown Splice Site ENU
    sa11703 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43597 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-specc1lb N/A 1
    MO2-specc1lb N/A 2
    DISEASE ASSOCIATED WITH specc1lb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    oblique facial clefting 1 Alliance ?Facial clefting, oblique, 1 600251
    Opitz GBBB syndrome type II Alliance Opitz GBBB syndrome, type II 145410
    Hypertelorism, Teebi type 145420
    DISEASE ASSOCIATED WITH specc1lb VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    orofacial cleft zf393Tg + MO2-specc1lb standard conditions Gfrerer et al., 2014
    WT + MO2-specc1lb standard conditions Gfrerer et al., 2014
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cranial skeletal system development (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA specc1lb-201 (1)    Ensembl 3722
    specc1lb-202 (1)    Ensembl 317
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-specc1l polyclonal Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM specc1lb No data available
    MARKER RELATIONSHIPS
    specc1lb Contained in: [BAC] CH73-68C19 (1), DKEY-156G19 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005161102 (1)
    Genomic GenBank:CU466275 (1) 104457 nt
    Select Tool
    Polypeptide UniProtKB:E7FG55 (1) 1121 aa
    Sequence Information (all 15)
    ORTHOLOGY for specc1lb ( Chr: 21 )
    CITATIONS (20)