ZFIN ID: ZDB-GENE-090423-1
Gene Name: sperm antigen with calponin homology and coiled-coil domains 1-like b
Gene Symbol: specc1lb
Sequence Ontology ID : SO:0000704

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Previous Name: cytsab

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in frontonasal suture morphogenesis; predicted to localize to the filamentous actin and microtubule organizing center; used to study orofacial cleft; orthologous to human SPECC1L (sperm  ...
GENE EXPRESSION
All Expression Data: Fig. 3 from Gfrerer et al., 2014
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011406Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6665 Point Mutation Unknown Splice Site ENU
    sa11703 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43597 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 5 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH specc1lb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Opitz-GBBB syndrome Opitz GBBB syndrome, type II 145410
    ?Facial clefting, oblique, 1 600251
    Hypertelorism, Teebi type 145420
    Hypertelorism, Teebi type 145420
    DISEASE ASSOCIATED WITH specc1lb VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    orofacial cleft zf393Tg + MO2-specc1lb standard conditions Gfrerer et al., 2014
    WT + MO2-specc1lb standard conditions Gfrerer et al., 2014
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cranial skeletal system development (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001715 (1)
  • InterPro:IPR036872 (1)
  • InterPro:IPR040166 (1)
  • PROSITE:PS50021 (1)
  • Pfam:PF00307 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA specc1lb-001 (1) 3722
    specc1lb-002 (1) 317
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM specc1lb No data available
    MARKER RELATIONSHIPS
    specc1lbContained in: [BAC] CH73-68C19 (1) (order this), DKEY-156G19 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005161102 (1)
    Genomic GenBank:CU466275 (1) 104457bp
    Select Tool
    Polypeptide UniProtKB:E7FG55 (1) 1121aa
    Sequence Clusters UniGene:87335 (1)
    Sequence Information (all 16)
    OTHER specc1lb GENE PAGES
  • Alliance (1)
  • Gene:555467 (1)
  • VEGA:OTTDARG00000031455 (1)
  • Ensembl(GRCz11):ENSDARG00000042232 (2)
  • ORTHOLOGY for specc1lb (Chr: 21)
    CITATIONS (18)