ZFIN ID: ZDB-GENE-090313-95
Gene Name: CD40 molecule, TNF receptor superfamily member 5
Gene Symbol: cd40    Nomenclature History

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Previous Names: si:ch211-231h20.3 (1), tnfsrf5 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits CD154 receptor binding activity. Involved in TRIF-dependent toll-like receptor signaling pathway. Localizes to external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; arthritis (multiple); autoimmune hypersensitivity disease (multiple); hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human CD40 (CD40 molecule).
Genome Resources: Alliance (1),  Gene:100270764 (1),  Ensembl(GRCz11):ENSDARG00000054968 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cd40 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency with hyper IgM type 3 Alliance Immunodeficiency with hyper-IgM, type 3 606843
DISEASE ASSOCIATED WITH cd40 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process TRIF-dependent toll-like receptor signaling pathway (more)
Cellular Component external side of plasma membrane (more)
Molecular Function CD154 receptor binding (more)
GO Terms (all 27)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cd40-201 (1)    Ensembl 1175
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-cd40 IgG Rabbit 2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cd40 No data available
MARKER RELATIONSHIPS
cd40 Contained in: [BAC] CH211-231H20 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001145246 (1) 1617 nt
Genomic GenBank:CR381544 (1) 146827 nt
Select Tool
Polypeptide UniProtKB:B8X730 (1) 286 aa
Sequence Information (all 7)
ORTHOLOGY for cd40 ( Chr: 23 )
CITATIONS (27)