Gene

cd40

ID
ZDB-GENE-090313-95
Name
CD40 molecule, TNF receptor superfamily member 5
Symbol
cd40 Nomenclature History
Previous Names
  • si:ch211-231h20.3 (1)
  • tnfsrf5 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Exhibits CD154 receptor binding activity. Involved in TRIF-dependent toll-like receptor signaling pathway. Localizes to external side of plasma membrane. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Gong et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cd40 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency with hyper IgM type 3 Alliance Immunodeficiency with hyper-IgM, type 3 606843
Associated With cd40 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001368 TNFR/NGFR cysteine-rich region
Domain Details Per Protein
Protein Length TNFR/NGFR cysteine-rich region
UniProtKB:B8X730 286
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cd40 IgG Rabbit
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations