Gene

dna2

ID
ZDB-GENE-090313-71
Name
DNA replication helicase/nuclease 2
Symbol
dna2 Nomenclature History
Previous Names
  • si:ch211-1n9.7 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have 5'-flap endonuclease activity and RNA binding activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis and replication fork reversal. Predicted to localize to cytoplasm and nuclear chromosome, telomeric region. Is expressed in ovary. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy. Orthologous to human DNA2 (DNA replication helicase/nuclease 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Yang et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dna2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 6 615156
Rothmund-Thomson syndrome, type 4 620819
Seckel syndrome 8 615807
Associated With dna2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR014808 DNA replication factor Dna2, N-terminal
Domain IPR026851 DNA replication ATP-dependent helicase/nuclease Dna2/JHS1, DEXXQ-box helicase domain
Domain IPR041677 DNA2/NAM7 helicase, helicase domain
Domain IPR041679 DNA2/NAM7 helicase-like, C-terminal
Domain IPR047187 Upf1-like, C-terminal helicase domain
Domain IPR048459 DNA2, rift barrel domain
Family IPR045055 DNA2/NAM7-like helicase
Homologous_superfamily IPR011604 PD-(D/E)XK endonuclease-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length DNA2/NAM7 helicase, helicase domain DNA2/NAM7 helicase-like, C-terminal DNA2/NAM7-like helicase DNA2, rift barrel domain DNA replication ATP-dependent helicase/nuclease Dna2/JHS1, DEXXQ-box helicase domain DNA replication factor Dna2, N-terminal PD-(D/E)XK endonuclease-like domain superfamily P-loop containing nucleoside triphosphate hydrolase Upf1-like, C-terminal helicase domain
UniProtKB:A0A8N7TD02 1371
UniProtKB:A0A8M9PSF9 1374
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA dna2-201 (1) Ensembl 4490 nt
mRNA dna2-202 (1) Havana 4753 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations