ZFIN ID: ZDB-GENE-090313-71
Gene Name: DNA replication helicase/nuclease 2
Gene Symbol: dna2    Nomenclature History

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Previous Name: si:ch211-1n9.7 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have 5'-flap endonuclease activity; RNA binding activity; and site-specific endodeoxyribonuclease activity, specific for altered base. Predicted to be involved in mitochondrial DNA replication; nucleic acid metabolic process; and positive regulation of DNA replication. Predicted to colocalize with gamma DNA polymerase complex. Is expressed in ovary. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy. Orthologous to human DNA2 (DNA replication helicase/nuclease 2).
Genome Resources: Alliance (1),  Gene:559535 (1),  Ensembl(GRCz11):ENSDARG00000078759 (2)
GENE EXPRESSION
All Expression Data: Fig. S2 from Yang et al., 2013
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dna2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6 Alliance Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 6 615156
Seckel syndrome 8 Alliance ?Seckel syndrome 8 615807
DISEASE ASSOCIATED WITH dna2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process DNA metabolic process (more)
Cellular Component mitochondrion (more)
Molecular Function 4 iron, 4 sulfur cluster binding (more)
GO Terms (all 26)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dna2-202 (1)    Ensembl 4753
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dna2 No data available
MARKER RELATIONSHIPS
dna2 Contained in: [BAC] CH211-1N9 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_682882 (1) 4510 nt
Genomic GenBank:BX530068 (1) 185626 nt
Select Tool
Polypeptide UniProtKB:F1Q892 (1) 1378 aa
Sequence Information (all 19)
ORTHOLOGY for dna2 ( Chr: 13 )
CITATIONS (22)