Gene

dna2

ID
ZDB-GENE-090313-71
Name
DNA replication helicase/nuclease 2
Symbol
dna2 Nomenclature History
Previous Names
  • si:ch211-1n9.7 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have 5'-flap endonuclease activity and RNA binding activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis and replication fork reversal. Predicted to localize to cytoplasm and nuclear chromosome, telomeric region. Is expressed in ovary. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy. Orthologous to human DNA2 (DNA replication helicase/nuclease 2).
Genome Resources
Note
None
Expression
All Expression Data
from Yang et al., 2013
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dna2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6 Alliance Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 6 615156
Seckel syndrome 8 Alliance ?Seckel syndrome 8 615807
Associated With dna2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR014808 DNA replication factor Dna2, N-terminal
Domain IPR041677 DNA2/NAM7 helicase, helicase domain
Domain IPR041679 DNA2/NAM7 helicase-like, C-terminal
Family IPR026851 DNA replication ATP-dependent helicase/nuclease Dna2
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length DNA2/NAM7 helicase, helicase domain DNA2/NAM7 helicase-like, C-terminal DNA replication ATP-dependent helicase/nuclease Dna2 DNA replication factor Dna2, N-terminal P-loop containing nucleoside triphosphate hydrolase
UniProtKB:B8A5D8 1374
UniProtKB:F1Q892 1378
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations