ZFIN ID: ZDB-GENE-090313-68
Gene Name: carboxypeptidase E
Gene Symbol: cpe    Nomenclature History

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Previous Names: si:ch211-198g9.2, zgc:85981

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to localize to extracellular space. Is expressed in posterior pancreatic bud and retina. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CPE (carboxypeptidase E).
Genome Resources: Alliance (1),  Gene:407979 (1),  Ensembl(GRCz11):ENSDARG00000055874 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013595Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko396a Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cpe 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cpe HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cpe VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular space (more)
    Molecular Function metallocarboxypeptidase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cpe-201 (1)    Ensembl 5597
    ncRNA cpe-002 (1) 801
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cpe No data available
    MARKER RELATIONSHIPS
    cpe Contained in: [BAC] CH211-198G9 (1), DKEYP-72G6 (1)
    cpe Encodes: [cDNA] MGC:85981 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_214810 (1) 4523 nt
    Genomic GenBank:BX119983 (1) 172227 nt
    Select Tool
    Polypeptide UniProtKB:Q6NSM5
    Sequence Information (all 9)
    ORTHOLOGY for cpe ( Chr: 1 )
    CITATIONS (24)