ZFIN ID: ZDB-GENE-090313-51
Gene Name: paired like homeobox 2Ba
Gene Symbol: phox2ba    Nomenclature History

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Previous Name: si:ch211-157h5.5

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human PHOX2B (paired like homeobox 2B).
Genome Resources: Alliance (1),  Gene:795258 (1),  Ensembl(GRCz11):ENSDARG00000075330 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013586Tg Transgenic Insertion Unknown Unknown DNA
zko361a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko361b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-phox2ba 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH phox2ba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital central hypoventilation syndrome Alliance Central hypoventilation syndrome, congenital, with or without Hirschsprung disease 209880
    Neuroblastoma with Hirschsprung disease 613013
    {Neuroblastoma, susceptibility to, 2} 613013
    DISEASE ASSOCIATED WITH phox2ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA phox2ba-201 (1)    Ensembl 872
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM phox2ba No data available
    MARKER RELATIONSHIPS
    phox2ba Contained in: [BAC] CH211-157H5 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001145703 (1)
    Genomic GenBank:BX323984 (1) 177080 nt
    Select Tool
    Polypeptide UniProtKB:B8A4X8 (1) 155 aa
    Sequence Information (all 4)
    ORTHOLOGY for phox2ba ( Chr: 1 )
    CITATIONS (19)