Gene

palb2

ID
ZDB-GENE-090313-43
Name
partner and localizer of BRCA2
Symbol
palb2 Nomenclature History
Previous Names
  • fancn (1)
  • Fanconi anemia, complementation group N
  • si:ch211-14k19.9
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group N; breast cancer; and pancreatic cancer. Is expressed in brain; eye; immature eye; lens; and pectoral fin fold. Orthologous to human PALB2 (partner and localizer of BRCA2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Titus et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Ramanagoudr-Bhojappa et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With palb2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance {Breast cancer, susceptibility to} 114480
Fanconi anemia complementation group N Alliance Fanconi anemia, complementation group N 610832
{Pancreatic cancer, susceptibility to, 3} 613348
Associated With palb2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR031920 Partner and localiser of BRCA2, WD40 domain
Family IPR042417 Partner and localizer of BRCA2
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Domain Details Per Protein
Protein Length Partner and localiser of BRCA2, WD40 domain Partner and localizer of BRCA2 WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:F1REG4 459
UniProtKB:E9QGW5 131
UniProtKB:B5TXG1 231
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations