ZFIN Gene: plcl1

ZFIN ID: ZDB-GENE-090313-194

ZFIN ID: ZDB-GENE-090313-194

Gene Name:

phospholipase C like 1

Gene Symbol:

plcl1 Nomenclature History

Previous Name:

si:dkey-15m21.1

Gene Type:

protein_coding_gene

Location:

Chr: 9 Mapping Details/Browsers

Description:

Predicted to have GABA receptor binding activity; inositol 1,4,5 trisphosphate binding activity; and phosphatidylinositol phospholipase C activity. Predicted to be involved in inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Is expressed in hindbrain; lateral line nerve; and spinal cord. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)).

Genome Resources:

Alliance (1), Gene:563105 (1), Ensembl(GRCz11):ENSDARG00000067676 (2)

GENE EXPRESSION
All Expression Data:	2 figures from Takada et al., 2010
Wild-type Stages, Structures:	Larval:Day 4 (96.0h-120.0h) to Larval:Day 4 (96.0h-120.0h)
	hindbrain oligodendrocyte lateral line nerve myelinating Schwann cell spinal cord oligodendrocyte

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
a323	Complex	Unknown	Unknown	CRISPR
la026917Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa2490	Point Mutation	Unknown	Splice Site	ENU
sa21517	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa31726	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34681	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa41457	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-plcl1	a323	1
CRISPR2-plcl1	a323	1
CRISPR3-plcl1	a323	1
CRISPR4-plcl1	a323	1

PHENOTYPE

Data:	Fig. S4 from Thyme et al., 2019
Observed in:	startle response swimming

DISEASE ASSOCIATED WITH plcl1 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH plcl1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	intracellular signal transduction (more)
Molecular Function	GABA receptor binding (more)

GO Terms (all 11)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	plcl1-201 (1)	3376	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM plcl1 No data available

MARKER RELATIONSHIPS

plcl1 Contained in:

[BAC] CH211-117M22 (1), DKEY-15M21 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_001921763 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CR391943 (1)	212667 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:F1Q7A3 (1)	1125 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 11)

ORTHOLOGY for plcl1 ( Chr: 9 )

CITATIONS (22)

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