ZFIN ID: ZDB-GENE-090313-194
Gene Name: phospholipase C like 1
Gene Symbol: plcl1    Nomenclature History

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Previous Name: si:dkey-15m21.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have GABA receptor binding activity; inositol 1,4,5 trisphosphate binding activity; and phosphatidylinositol phospholipase C activity. Predicted to be involved in inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Is expressed in hindbrain; lateral line nerve; and spinal cord. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)).
Genome Resources: Alliance (1),  Gene:563105 (1),  Ensembl(GRCz11):ENSDARG00000067676 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a323 Complex Unknown Unknown CRISPR
la026917Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2490 Point Mutation Unknown Splice Site ENU
    sa21517 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31726 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34681 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41457 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-plcl1 1
    CRISPR2-plcl1 1
    CRISPR3-plcl1 1
    CRISPR4-plcl1 1
    PHENOTYPE
    Data: Fig. S4 from Thyme et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH plcl1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH plcl1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Molecular Function GABA receptor binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA plcl1-201 (1)    Ensembl 3376
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM plcl1 No data available
    MARKER RELATIONSHIPS
    plcl1 Contained in: [BAC] CH211-117M22 (1), DKEY-15M21 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001921763 (1)
    Genomic GenBank:CR391943 (1) 212667 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q7A3 (1) 1125 aa
    Sequence Information (all 11)
    ORTHOLOGY for plcl1 ( Chr: 9 )
    CITATIONS (22)