ZFIN ID: ZDB-GENE-090312-103
Gene Name: docking protein 7
Gene Symbol: dok7    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: si:ch211-164d19.2, si:dkey-180b4.3

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have protein kinase binding activity. Involved in skeletal muscle fiber development; synapse organization; and thigmotaxis. Is expressed in post-vent region and tail bud. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 10 and fetal akinesia deformation sequence syndrome 3. Orthologous to human DOK7 (docking protein 7).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000060236 (1)
GENE EXPRESSION
All Expression Data: Fig. 2 from Müller et al., 2010
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013665Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • p189 Small Deletion Exon 3 Unknown TALEN
    sa45077 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45078 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dok7 N/A 1
    MO2-dok7 N/A 2
    TALEN1-dok7 1
    DISEASE ASSOCIATED WITH dok7 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital myasthenic syndrome 10 Alliance Myasthenic syndrome, congenital, 10 254300
    fetal akinesia deformation sequence syndrome 3 Alliance Fetal akinesia deformation sequence 3 618389
    DISEASE ASSOCIATED WITH dok7 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neuromuscular junction development (more)
    Molecular Function protein kinase binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dok7-202 (1)    Ensembl 2948
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dok7 No data available
    MARKER RELATIONSHIPS
    dok7 Contained in: [BAC] CH211-164D19 (1), DKEY-180B4 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:AL954671 (1) 142357 nt
    Select Tool
    Polypeptide UniProtKB:F6P2Z4 (1) 695 aa
    Sequence Information (all 4)
    ORTHOLOGY for dok7 ( Chr: 1 )
    CITATIONS (19)