ZFIN ID: ZDB-GENE-090212-1
Gene Name: alpha-2-macroglobulin-like
Gene Symbol: a2ml    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have endopeptidase inhibitor activity. Involved in liver development. Predicted to localize to extracellular space. Is expressed in gut; liver; yolk; and yolk syncytial layer.
Genome Resources: Alliance (1),  Gene:100006972 (1),  Ensembl(GRCz11):ENSDARG00000056314 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6372 Point Mutation Unknown Premature Stop ENU
sa10524 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12900 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-a2ml N/A 2
    MO2-a2ml N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH a2ml HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH a2ml VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process liver development (more)
    Cellular Component extracellular region (more)
    Molecular Function endopeptidase inhibitor activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA a2ml-201 (1)    Ensembl 4537
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM a2ml No data available
    MARKER RELATIONSHIPS
    a2ml Contained in: [BAC] DKEY-52D15 (1) (order this)
    a2ml Encodes: [EST] fc90g08
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001139479 (1) 4566 nt
    Genomic GenBank:CR626907 (1) 206211 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F6NTZ9 (1) 1448 aa
    Sequence Information (all 21)
    ORTHOLOGY for a2ml ( Chr: 15 )
    CITATIONS (25)