Gene

disc1

ID
ZDB-GENE-090122-1
Name
DISC1 scaffold protein
Symbol
disc1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Acts upstream of or within several processes, including animal organ development; oligodendrocyte cell fate specification; and regulation of gastrulation. Predicted to be active in cytoskeleton and mitochondrion. Is expressed in several structures, including cranial cartilage; immature eye; nervous system; neural crest; and notochord. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Orthologous to human DISC1 (DISC1 scaffold protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With disc1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
schizophrenia 9 Alliance {Schizophrenia 9, susceptibility to} 604906
Associated With disc1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR026081 Disrupted in schizophrenia 1
Domain Details Per Protein
Protein Length Disrupted in schizophrenia 1
UniProtKB:B8PWL7 994
UniProtKB:F1QQ50 994
UniProtKB:Q8AV88 963
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations