ZFIN ID: ZDB-GENE-090112-3
Gene Name: fibrillin 2b
Gene Symbol: fbn2b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: fbn2 (1), pfd (1), puff daddy (1), sco, scoth tape (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have extracellular matrix structural constituent. Involved in several processes, including circulatory system development; notochord morphogenesis; and regulation of cell proliferation involved in heart valve morphogenesis. Predicted to localize to extracellular matrix. Is expressed in several structures, including epidermis; hypoblast; hypochord; immature eye; and paraxial mesoderm. Human ortholog(s) of this gene implicated in congenital contractural arachnodactyly and scoliosis. Orthologous to several human genes including FBN3 (fibrillin 3).
Genome Resources: Alliance (1),  Gene:571786 (1),  Ensembl(GRCz11):ENSDARG00000098237 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gw1 Point Mutation Unknown Premature Stop
la014257Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022362Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12625 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13470 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16275 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24062 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43757 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • te382 Complex Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • te382a Point Mutation Unknown Missense ENU
    tt239 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fbn2b
    2
    CRISPR2-fbn2b
    2
    MO1-fbn2b N/A 3
    MO2-fbn2b N/A 1
    MO3-fbn2b N/A 1
    DISEASE ASSOCIATED WITH fbn2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital contractural arachnodactyly Alliance Contractural arachnodactyly, congenital 121050
    distal arthrogryposis Alliance Contractural arachnodactyly, congenital 121050
    Macular degeneration, early-onset 616118
    DISEASE ASSOCIATED WITH fbn2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion (more)
    Cellular Component extracellular matrix (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fbn2b-201 (1)    Ensembl 931
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fbn2b No data available
    MARKER RELATIONSHIPS
    fbn2b Contained in: [BAC] DKEY-241F21 (1) (order this)
    [Fosmid] ZFOS-412G11 (1)
    fbn2b Encodes: [EST] wz12651
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001135790 (1) 8607 nt
    Genomic GenBank:CR751224 (1) 151612 nt
    Select Tool
    Polypeptide UniProtKB:A0A0G2KQ62 (1) 2868 aa
    Sequence Information (all 16)
    ORTHOLOGY for fbn2b ( Chr: 22 )
    CITATIONS (35)