Gene

il1rapl1b

ID
ZDB-GENE-090109-2
Name
interleukin 1 receptor accessory protein-like 1b
Symbol
il1rapl1b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have NAD(P)+ nucleosidase activity and NAD+ nucleotidase, cyclic ADP-ribose generating. Involved in neuron remodeling and synapse organization. Localizes to axon terminus and neuronal cell body. Is expressed in olfactory bulb; optic tectum; peripheral olfactory organ; and telencephalon. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1).
Genome Resources
Note
None
Expression
All Expression Data
from Yoshida et al., 2008
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Yoshida et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il1rapl1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability 21 Alliance Mental retardation, X-linked 21/34 300143
Associated With il1rapl1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR041416 IL-1Ra-like, immunoglobulin domain
Family IPR015621 Interleukin-1 receptor family
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length IL-1Ra-like, immunoglobulin domain Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Interleukin-1 receptor family Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily
UniProtKB:B6ZK77 700
UniProtKB:A0A0G2KHJ0 468
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations