ZFIN Gene: sox6

ZFIN ID: ZDB-GENE-081120-6

ZFIN ID: ZDB-GENE-081120-6

Gene Name:

SRY-box transcription factor 6

Gene Symbol:

sox6 Nomenclature History

Previous Names:

sox6b (1), fc35a10, fc50e03, wu:fc35a10, wu:fc50e03

Gene Type:

protein_coding_gene

Location:

Chr: 7 Mapping Details/Browsers

Description:

Predicted to have transcription regulatory region sequence-specific DNA binding activity. Involved in adipose tissue development; muscle cell fate specification; and skeletal muscle tissue development. Predicted to localize to nucleus. Is expressed in fast muscle cell; myotome; pharyngeal arch 3-7; and somite. Human ortholog(s) of this gene implicated in malignant glioma. Orthologous to human SOX6 (SRY-box transcription factor 6).

Genome Resources:

Alliance (1), Gene:567154 (1), Ensembl(GRCz11):ENSDARG00000015536 (2)

GENE EXPRESSION
All Expression Data:	8 figures from 7 publications
Wild-type Stages, Structures:	Segmentation:10-13 somites (14.0h-16.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	fast muscle cell myotome pharyngeal arch 3-7 somite fast muscle cell whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
i291	Unknown	Unknown	Unknown	ZINC_FINGER_NUCLEASE
i292	Unknown	Unknown	Unknown	ZINC_FINGER_NUCLEASE
la016058Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la016060Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la025941Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa9376	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20951	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38612	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44663	Point Mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
sa45277	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
tud38Gt	Transgenic Insertion	Intron 4	Unknown	DNA

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-sox6	N/A	2

PHENOTYPE

Data:	10 figures from 3 publications
Observed in:	adipose tissue development fast muscle cell calcium-mediated signaling fast muscle cell nucleus fast muscle cell optic tectum pleuroperitoneal cavity lipid droplet slow muscle cell swimming thigmotaxis vertebral column whole organism

DISEASE ASSOCIATED WITH sox6 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH sox6 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	skeletal muscle tissue development (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 12)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	sox6-203 (1)	6184	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	sox6-205 (1)	749	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	sox6-206 (1)	7908	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	sox6-002 (1)	874	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	sox6-003 (1)	724	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-sox6			Rabbit	IHC		2

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM sox6

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(-1.5sox6:EGFP)	sox6	EGFP	Danio rerio	1	3
Tg(-2.8sox6:EGFP)	sox6	EGFP	Danio rerio	1	3
Tg(-2.8sox6:mCherry)	sox6	mCherry	Danio rerio	1	3
Tg(-2sox6:EGFP)	sox6	EGFP	Danio rerio	1	3
Tg(-7.6sox6:EGFP)	sox6	EGFP	Danio rerio	1	5
Tg(sox6:mCherry)	sox6	mCherry	Danio rerio	1	3
Tg(UAS:sox6-EGFP)	UAS	EGFP, sox6	Danio rerio	1	2
Tg1(-2.8sox6:EGFP-UTR-sox6)	sox6	EGFP	Danio rerio	1	3
Tg2(-2.8sox6:EGFP-UTR-sox6)	sox6	EGFP	Danio rerio	1	3
Tg3(-2.8sox6:EGFP-UTR-sox6)	sox6	EGFP	Danio rerio	1	3

MARKER RELATIONSHIPS

sox6 Contained in:	[BAC] DKEY-48H11 (1) (order this), DKEY-246O4 (1) (order this), DKEYP-93A2 (1)
sox6 Encodes:	[EST] fc35a10, fc50e03

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001123009 (1)	2350 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX537340 (1)	192070 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A2R8QLT0 (1)	816 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 31)

ORTHOLOGY for sox6 ( Chr: 7 )

CITATIONS (44)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: