Gene
sox6
- ID
- ZDB-GENE-081120-6
- Name
- SRY-box transcription factor 6
- Symbol
- sox6 Nomenclature History
- Previous Names
-
- sox6b (1)
- fc35a10
- fc50e03
- wu:fc35a10
- wu:fc50e03
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within adipose tissue development; muscle cell fate specification; and skeletal muscle tissue development. Predicted to be active in nucleus. Is expressed in intermuscular bone; muscle; pharyngeal arch 3-7; somite; and telencephalon. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SOX6 (SRY-box transcription factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Tolchin-Le Caignec syndrome | 618971 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | SOX/SOX-like transcription factors |
|---|---|---|---|---|---|
| UniProtKB:B2CNY6 | InterPro | ||||
| UniProtKB:F8W2H3 | InterPro | 768 | |||
| UniProtKB:A0A8M1NI90 | InterPro | 785 | |||
| UniProtKB:A0AB32TRN6 | InterPro | 816 | |||
| UniProtKB:A0AB32TRQ1 | InterPro | 817 | |||
| UniProtKB:A0AB32TSK4 | InterPro | 805 | |||
| UniProtKB:A0AB32TT03 | InterPro | 806 | |||
| UniProtKB:A0AB32TV27 | InterPro | 814 | |||
| UniProtKB:A0AB32TWV8 | InterPro | 837 | |||
| UniProtKB:A0AB32TXE9 | InterPro | 834 | |||
| UniProtKB:A0AB32TYJ0 | InterPro | 817 | |||
| UniProtKB:A0AB32TYM8 | InterPro | 789 | |||
| UniProtKB:A0AB32TYP5 | InterPro | 836 | |||
| UniProtKB:A0AB32TZS8 | InterPro | 836 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sox6-201
(1)
|
Ensembl | 2,350 nt | ||
| mRNA |
sox6-203
(1)
|
Ensembl | 6,184 nt | ||
| mRNA |
sox6-205
(1)
|
Ensembl | 749 nt | ||
| mRNA |
sox6-206
(1)
|
Ensembl | 7,908 nt | ||
| mRNA |
sox6-207
(1)
|
Ensembl | 2,385 nt | ||
| mRNA |
sox6-208
(1)
|
Ensembl | 3,004 nt | ||
| mRNA |
sox6-209
(1)
|
Ensembl | 2,639 nt | ||
| mRNA |
sox6-210
(1)
|
Ensembl | 3,045 nt | ||
| ncRNA |
sox6-002
(1)
|
Ensembl | 874 nt | ||
| ncRNA |
sox6-003
(1)
|
Ensembl | 724 nt |
Interactions and Pathways
No data available
Plasmids
No data available