ZFIN ID: ZDB-GENE-041105-6
Gene Name: procollagen, type V, alpha 1
Gene Symbol: col5a1    Nomenclature History

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Previous Name: si:dkey-87m23.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have extracellular matrix structural constituent and heparin binding activity. Predicted to be involved in cell adhesion and collagen fibril organization. Predicted to localize to the collagen type V trimer and extracellular space. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and type I Ehlers-Danlos syndrome. Is expressed in several structures, including dermis; head; neural crest; notochord; and otic vesicle. Orthologous to human COL5A1 (collagen type V alpha 1 chain).
Genome Resources: Alliance (1),  Gene:100334431 (1),  Ensembl(GRCz11):ENSDARG00000012593 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028380Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa4934 Point Mutation Unknown Splice Site ENU
    sa5957 Point Mutation Unknown Splice Site ENU
    sa23852 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37227 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37228 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43580 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45726 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-col5a1
    2
    MO1-col5a1 N/A 1
    MO2-col5a1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH col5a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    type I Ehlers-Danlos syndrome Alliance Ehlers-Danlos syndrome, classic type, 1 130000
    DISEASE ASSOCIATED WITH col5a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion (more)
    Cellular Component collagen trimer (more)
    Molecular Function extracellular matrix structural constituent (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000885 Fibrillar collagen, C-terminal
    Domain IPR001791 Laminin G domain
    Repeat IPR008160 Collagen triple helix repeat
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA col5a1-201 (1)    Ensembl 9581
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM col5a1 No data available
    MARKER RELATIONSHIPS
    col5a1 Contained in: [BAC] CH73-165E7 (1), CH73-331J9 (1), DKEY-87M23 (1) (order this)
    [Fosmid] CH1073-153C9 (1)
    col5a1 Has Artifact: [EST] fc69d06
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_021468998 (1)
    Genomic GenBank:FP102894 (1) 92532 bp
    Select Tool
    Polypeptide UniProtKB:F6NPA4 (1) 2011 aa
    Sequence Information (all 31)
    ORTHOLOGY for col5a1 ( Chr: 21 )
    CITATIONS (36)