ZFIN ID: ZDB-GENE-081104-387
Gene Name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Gene Symbol: huwe1
Sequence Ontology ID : SO:0000704

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Previous Names: sb:eu595, sb:eu633, sb:eu703, si:dkey-242a8.2

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(Including Attributions)
Location: Chr: 23 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have ubiquitin protein ligase activity; predicted to be involved in base-excision repair, protein polyubiquitination, and ubiquitin-dependent protein catabolic process; predicted to  ...
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu595]
  1 figure (1 image) from Thisse et al., 2005 [eu633]
  1 figure (1 image) from Thisse et al., 2005 [eu703]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022631Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa618 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15608 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17915 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24357 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24358 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30743 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37738 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37739 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37740 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37741 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39413 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44001 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44002 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH huwe1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Mental retardation, X-linked syndromic, Turner type 309590
    DISEASE ASSOCIATED WITH huwe1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cytoplasm (more)
    Molecular Function transferase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000569 (1)
  • InterPro:IPR004170 (1)
  • InterPro:IPR009060 (1)
  • InterPro:IPR010309 (1)
  • InterPro:IPR010314 (1)
  • InterPro:IPR015940 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR018123 (1)
  • InterPro:IPR025527 (1)
  • InterPro:IPR035983 (1)
  • InterPro:IPR037197 (1)
  • PROSITE:PS50030 (1)
  • PROSITE:PS50237 (1)
  • PROSITE:PS50918 (1)
  • Pfam:PF00627 (1)
  • Pfam:PF00632 (1)
  • Pfam:PF02825 (1)
  • Pfam:PF06012 (1)
  • Pfam:PF06025 (1)
  • Pfam:PF14377 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA huwe1-202 (1) 14397
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM huwe1 No data available
    MARKER RELATIONSHIPS
    huwe1Contained in: [BAC] DKEY-242A8 (1) (order this)
    huwe1Encodes: [EST] eu595 (1), eu633 (1), eu703 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001365654 (1)
    Genomic GenBank:BX664745 (1) 261934bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QL68 (1) 4474aa
    Sequence Information (all 46)
    OTHER huwe1 GENE PAGES
  • Alliance (1)
  • Gene:559439 (1)
  • VEGA:OTTDARG00000028138 (1)
  • Ensembl(GRCz11):ENSDARG00000016782 (2)
  • ORTHOLOGY for huwe1 (Chr: 23)
    CITATIONS (25)