ZFIN ID: ZDB-GENE-081022-154
Gene Name: adrenoceptor beta 3b
Gene Symbol: adrb3b    Nomenclature History

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Previous Names: zgc:194843, zgc:194852

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have beta3-adrenergic receptor activity; epinephrine binding activity; and norepinephrine binding activity. Predicted to be involved in adenylate cyclase-activating adrenergic receptor signaling pathway; cell-cell signaling; and norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure. Predicted to localize to integral component of plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; non-alcoholic fatty liver disease; and obesity. Orthologous to human ADRB3 (adrenoceptor beta 3).
Genome Resources: Alliance (1),  Gene:792519 (1),  Ensembl(GRCz11):ENSDARG00000052919 (1)
GENE EXPRESSION
All Expression Data: Fig. 3 from Wang et al., 2009
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9199 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-adrb3b N/A 1
    DISEASE ASSOCIATED WITH adrb3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    obesity Alliance {Obesity, susceptibility to} 601665
    DISEASE ASSOCIATED WITH adrb3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function G protein-coupled receptor activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adrb3b-201 (1)    Ensembl 1676
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adrb3b No data available
    MARKER RELATIONSHIPS
    adrb3b Contained in: [BAC] CH211-271B8 (1)
    adrb3b Encodes: [cDNA] MGC:194843 (1), MGC:194852 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001135134 (1)
    Genomic GenBank:BX005297 (1) 156906 nt
    Select Tool
    Polypeptide UniProtKB:B3DIE4 (1) 405 aa
    Sequence Information (all 16)
    ORTHOLOGY for adrb3b ( Chr: 10 )
    CITATIONS (18)