Gene

htr1b

ID
ZDB-GENE-081022-141
Name
5-hydroxytryptamine (serotonin) receptor 1B
Symbol
htr1b Nomenclature History
Previous Names
  • zgc:194666
  • zgc:194690
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within several processes, including G protein-coupled receptor signaling pathway; bone remodeling; and vasoconstriction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in central nervous system; pharynx; and retina. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With htr1b Human Ortholog
No data available
Associated With htr1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR002147 5-Hydroxytryptamine 1B receptor
Family IPR002231 5-hydroxytryptamine receptor family
Domain Details Per Protein
Protein Length 5-Hydroxytryptamine 1B receptor 5-hydroxytryptamine receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:B3DK14 380
UniProtKB:F6NR34 385
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations