Gene

appl2

ID
ZDB-GENE-081016-2
Name
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Symbol
appl2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have gamma-tubulin binding activity. Predicted to be involved in signaling. Localizes to endosome. Is expressed in hindbrain; peripheral olfactory organ; and spinal cord. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Schenck et al., 2008
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Schenck et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With appl2 Human Ortholog
No data available
Associated With appl2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001849 Pleckstrin homology domain
Domain IPR006020 PTB/PI domain
Domain IPR040457 Gamma tubulin complex component, C-terminal
Domain IPR041470 Gamma tubulin complex component protein, N-terminal
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR027267 AH/BAR domain superfamily
Homologous_superfamily IPR042241 Gamma-tubulin complex, C-terminal domain superfamily
Domain Details Per Protein
Protein Length AH/BAR domain superfamily Gamma tubulin complex component, C-terminal Gamma tubulin complex component protein, N-terminal Gamma-tubulin complex, C-terminal domain superfamily PH-like domain superfamily Pleckstrin homology domain PTB/PI domain
UniProtKB:B2XCM0 662
UniProtKB:A0A0R4IYK8 1678
UniProtKB:F1RB27 662
UniProtKB:A0A0G2KGM8 1649
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-appl2 monoclonal Mouse
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations