ZFIN ID: ZDB-GENE-081016-2
Gene Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Gene Symbol: appl2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have gamma-tubulin binding activity. Predicted to be involved in signaling. Localizes to endosome. Is expressed in hindbrain; peripheral olfactory organ; and spinal cord. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2).
Genome Resources: Alliance (1),  Gene:100000135 (1),  Ensembl(GRCz11):ENSDARG00000100151 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37994 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39469 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44227 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf119 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-appl2 N/A 1
    DISEASE ASSOCIATED WITH appl2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH appl2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process microtubule cytoskeleton organization (more)
    Cellular Component endosome (more)
    Molecular Function protein binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-appl2 monoclonal Mouse WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM appl2 No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128075 (1) 2127 nt
    Polypeptide UniProtKB:A0A0R4IYK8 (1) 1678 aa
    Sequence Information (all 11)
    ORTHOLOGY for appl2 ( Chr: 25 )
    CITATIONS (15)