ZFIN ID: ZDB-GENE-081016-1
Gene Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Gene Symbol: appl1
Location: Chr: 11   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from Schenck et al., 2008
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Long-pec (48.0h-60.0h)
  hindbrain, neural keel, neural tube, olfactory placode (all 10) expand
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 2 genotypes
Alleles: hu3559
Knockdown reagents: MO1-appl1 (1), MO2-appl1 (1)
PHENOTYPE
Data: 5 figures from Schenck et al., 2008
Observed in: embryo development, extension, forebrain, olfactory bulb (all 7) expand
GENE ONTOLOGY
Ontology GO Term
Cellular Component early endosome (more)
Molecular Function protein binding (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001849 (1)
  • InterPro:IPR006020 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR027267 (1)
  • PROSITE:PS01179 (1)
  • PROSITE:PS50003 (1)
  • Pfam:PF00169 (1)
  • Pfam:PF00640 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-appl1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM appl1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128074 (1) 2234 bp
    Genomic GenBank:CABZ01075841 (1) 10961 bp
    Polypeptide UniProtKB:B2XCL9 (1) 707 aa
    Sequence Clusters UniGene:69911 (1)
    Sequence Information (all 13)
    OTHER appl1 GENE PAGES
  • Gene:571540 (1)
  • Ensembl(Zv9):ENSDARG00000060734 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish appl1 11  
    Human APPL1 3 (3p21.1-p14.3)
  • OMIM:604299
  • Gene:26060
  • Mouse Appl1 14 ( 16.09 cM)
  • MGI:1920243
  • Gene:72993
  • Orthology Details
    CITATIONS (9)