ZFIN ID: ZDB-GENE-081016-1
Gene Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Gene Symbol: appl1

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Location: Chr: 11 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from Schenck et al., 2008
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Long-pec (48.0h-60.0h)
  hindbrain, neural keel, neural tube, olfactory placode (all 10) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3559 Unknown Unknown Premature Stop ENU
Targeting reagents: MO1-appl1 (1), MO2-appl1 (1)
PHENOTYPE
Data: 5 figures from Schenck et al., 2008
Observed in: embryo development, extension, forebrain, olfactory bulb (all 7) expand
DISEASE ASSOCIATED WITH appl1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young {Maturity-onset diabetes of the young, type 14} 616511
GENE ONTOLOGY
Ontology GO Term
Cellular Component early endosome (more)
Molecular Function protein binding (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001849 (1)
  • InterPro:IPR006020 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR027267 (1)
  • PROSITE:PS01179 (1)
  • PROSITE:PS50003 (1)
  • Pfam:PF00169 (1)
  • Pfam:PF00640 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-appl1 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM appl1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPSNo data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128074 (1) 2234bp
    Genomic GenBank:CABZ01075841 (1) 10961bp
    Polypeptide UniProtKB:B2XCL9 (1) 707aa
    Sequence Clusters UniGene:69911 (1)
    Sequence Information (all 13)
    OTHER appl1 GENE PAGES
  • Gene:571540 (1)
  • Ensembl(GRCz10):ENSDARG00000060734 (1)
  • ORTHOLOGY for appl1 (Chr: 11)
    Species Symbol Chromosome Accession # Evidence
    Human APPL1 3
  • Gene:26060
  • OMIM:604299
  • HGNC:24035
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Appl1 14
  • MGI:1920243
  • Gene:72993
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (10)