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ZIRC
ZFIN ID: ZDB-GENE-081016-1
Gene Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Gene Symbol: appl1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have protein kinase B binding activity. Predicted to be involved in insulin receptor signaling pathway. Localizes to the early endosome. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Is expressed in nervous system; neural keel; neural tube; and pronephros. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1).
Genome Resources: Alliance (1),  Gene:571540 (1),  Ensembl(GRCz11):ENSDARG00000060734 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3559 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-appl1 N/A 1
MO2-appl1 N/A 1
DISEASE ASSOCIATED WITH appl1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 14 Alliance {Maturity-onset diabetes of the young, type 14} 616511
DISEASE ASSOCIATED WITH appl1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component early endosome (more)
Molecular Function protein binding (more)
GO Terms (all 4)
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-appl1 monoclonal Mouse IHC, WB 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM appl1 No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001128074 (1)
Genomic GenBank:CABZ01076721 (1) 3673 bp
Polypeptide UniProtKB:B2XCL9 (1) 707 aa
Sequence Clusters UniGene:69911 (1)
Sequence Information (all 13)
ORTHOLOGY for appl1 ( Chr: 11 )
CITATIONS (17)