Community Action Needed: Please respond to the NIH RFI
Gene

wnt3

ID
ZDB-GENE-081003-1
Name
wingless-type MMTV integration site family, member 3
Symbol
wnt3 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within cloaca development and thalamus development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including basal plate midbrain region; brain; midbrain hindbrain boundary neural tube; posterior neural tube; and presumptive diencephalon. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human WNT3 (Wnt family member 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Baranowska K├Ârberg et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wnt3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
tetraamelia syndrome 1 Alliance ?Tetra-amelia syndrome 1 273395
Associated With wnt3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018161 Wnt protein, conserved site
Family IPR005817 Wnt
Family IPR009141 Wnt-3 protein
Homologous_superfamily IPR043158 Wnt, C-terminal domain
Domain Details Per Protein
Protein Length Wnt Wnt-3 protein Wnt, C-terminal domain Wnt protein, conserved site
UniProtKB:B0LK22 355
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations