ZFIN ID: ZDB-GENE-081003-1
Gene Name: wingless-type MMTV integration site family, member 3
Gene Symbol: wnt3    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have frizzled binding activity. Involved in cloaca development and thalamus development. Predicted to localize to the extracellular space. Is expressed in several structures, including basal plate midbrain region; brain; midbrain hindbrain boundary neural tube; posterior neural tube; and presumptive diencephalon. Orthologous to human WNT3 (Wnt family member 3).
Genome Resources: Alliance (1),  Gene:569420 (1),  Ensembl(GRCz11):ENSDARG00000038990 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-wnt3 N/A 3
MO2-wnt3 N/A 1
MO3-wnt3 N/A 1
DISEASE ASSOCIATED WITH wnt3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Tetra-amelia syndrome 1 273395
DISEASE ASSOCIATED WITH wnt3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process thalamus development (more)
Cellular Component extracellular region (more)
Molecular Function signaling receptor binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR018161 Wnt protein, conserved site
Family IPR005817 Wnt
Family IPR009141 Wnt-3 protein
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA wnt3-201 (1)    Ensembl 1498
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM wnt3
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-4.0wnt3:EGFP) wnt3 EGFP Danio rerio 3 2
Tg(-4.0wnt3:wnt3-EGFP) wnt3 EGFPwnt3 Danio rerio 3 4
Tg(hsp70l:wnt3-GFP) hsp70l GFPwnt3 Danio rerio 1 3
MARKER RELATIONSHIPS
wnt3 Contained in: [BAC] CH211-177M15 (1), DKEY-29B5 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001114552 (1) 1500 nt
Genomic GenBank:CR388157 (1) 225145 nt Blast at MegaBLAST
Polypeptide UniProtKB:B0LK22 (1) 355 aa
Sequence Information (all 14)
ORTHOLOGY for wnt3 ( Chr: 12 )
CITATIONS (45)