Gene

hif1aa

ID
ZDB-GENE-080917-55
Name
hypoxia inducible factor 1 subunit alpha a
Symbol
hif1aa Nomenclature History
Previous Names
  • HIF1A (1)
  • Hif1b (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; macrophage migration; and regulation of angiogenesis. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Gerri et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hif1aa Human Ortholog
No data available
Associated With hif1aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000014 PAS domain
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR013655 PAS fold-3
Domain IPR013767 PAS fold
Domain IPR014887 HIF-1 alpha, transactivation domain, C-terminal
Family IPR021537 Hypoxia-inducible factor, alpha subunit
Homologous_superfamily IPR035965 PAS domain superfamily
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Repeat IPR001610 PAC motif
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily HIF-1 alpha, transactivation domain, C-terminal Hypoxia-inducible factor, alpha subunit Myc-type, basic helix-loop-helix (bHLH) domain PAC motif PAS domain PAS domain superfamily PAS fold PAS fold-3
UniProtKB:F1QEA3 708
UniProtKB:F1QFL2 189
UniProtKB:F1QNB9 717
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations