ZFIN ID: ZDB-GENE-080808-7
Gene Name: calcium channel, voltage-dependent, beta 2a
Gene Symbol: cacnb2a    Nomenclature History

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Previous Names: CAB2b.1 (1), CACNB2.1 (1), cacnb2b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have high voltage-gated calcium channel activity. Involved in embryonic heart tube morphogenesis; glial cell development; and retina development in camera-type eye. Predicted to localize to voltage-gated calcium channel complex. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2).
Genome Resources: Alliance (1),  Gene:795492 (1),  Ensembl(GRCz11):ENSDARG00000099045 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a246 Complex Unknown Unknown CRISPR
sa45305 Point Mutation Unknown Missense, Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cacnb2a
    1
    CRISPR2-cacnb2a 1
    CRISPR3-cacnb2a 1
    CRISPR4-cacnb2a 1
    CRISPR5-cacnb2a 1
    CRISPR10-cacnb2a
    1
    MO1-cacnb2a N/A 1
    MO2-cacnb2a N/A 1
    DISEASE ASSOCIATED WITH cacnb2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Brugada syndrome 4 Alliance Brugada syndrome 4 611876
    DISEASE ASSOCIATED WITH cacnb2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic heart tube morphogenesis (more)
    Cellular Component voltage-gated calcium channel complex (more)
    Molecular Function voltage-gated calcium channel activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript cacnb2a-203 (1)    Ensembl 1929
    cacnb2a-204 (1)    Ensembl 2207
    cacnb2a-207 (1)    Ensembl 2432
    cacnb2a-208 (1)    Ensembl 2206
    mRNA cacnb2a-201 (1)    Ensembl 1943
    cacnb2a-202 (1)    Ensembl 1795
    cacnb2a-205 (1)    Ensembl 1909
    cacnb2a-206 (1)    Ensembl 4132
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacnb2a No data available
    MARKER RELATIONSHIPS
    cacnb2a Contained in: [BAC] CH211-111G18 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001083568 (1) 1980 nt
    Genomic GenBank:CU607104 (1) 167602 nt
    Select Tool
    Polypeptide UniProtKB:B2XY76 (1) 637 aa
    Sequence Information (all 39)
    ORTHOLOGY for cacnb2a ( Chr: 7 )
    CITATIONS (19)