ZFIN ID: ZDB-GENE-080505-1
Gene Name: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Gene Symbol: ppargc1a    Nomenclature History

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Previous Names: PGC1 (1), ppargc1al, gb:dq017637

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have nuclear receptor transcription coactivator activity and transcription factor binding activity. Involved in late distal convoluted tubule development; proximal straight tubule development; and skeletal muscle tissue development. Predicted to localize to nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha).
Genome Resources: Alliance (1),  Gene:553418 (1),  Ensembl(GRCz11):ENSDARG00000067829 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns176 Indel Unknown Unknown CRISPR
sa7107 Point Mutation Unknown Premature Stop ENU
sa13186 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31621 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34242 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34243 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ppargc1a 1
    MO1-ppargc1a N/A 3
    MO2-ppargc1a N/A 2
    MO3-ppargc1a N/A 1
    MO4-ppargc1a N/A 1
    MO5-ppargc1a N/A 1
    MO6-ppargc1a N/A 1
    DISEASE ASSOCIATED WITH ppargc1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ppargc1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process late distal convoluted tubule development (more)
    Cellular Component nucleus (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ppargc1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(actc1b:3xflag-ppargc1a,cryaa:zsgfp) actc1bcryaa FLAGppargc1aZsGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    ppargc1a Encodes: [EST] dq017637 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002667531 (1)
    Genomic GenBank:HM012523 (1) 888 nt
    Polypeptide UniProtKB:F1QXB5 (1) 859 aa
    Sequence Information (all 38)
    ORTHOLOGY for ppargc1a ( Chr: 7 )
    CITATIONS (68)