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Gene

ppargc1a

ID
ZDB-GENE-080505-1
Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Symbol
ppargc1a Nomenclature History
Previous Names
  • PGC1 (1)
  • ppargc1al
  • gb:dq017637
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable nuclear receptor coactivator activity. Acts upstream of or within late distal convoluted tubule development; proximal straight tubule development; and skeletal muscle tissue development. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
31 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ppargc1a Human Ortholog
No data available
Associated With ppargc1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000504 RNA recognition motif domain
Family IPR034605 PGC-1
Family IPR034625 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily IPR035979 RNA-binding domain superfamily
Domain Details Per Protein
Protein Length Nucleotide-binding alpha-beta plait domain superfamily Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PGC-1 RNA-binding domain superfamily RNA recognition motif domain
UniProtKB:D6QWW9 56
UniProtKB:Q1L669 229
UniProtKB:D7F2U9 844
UniProtKB:F1QXB5 859
UniProtKB:Q52MY8 418
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-ppargc1a polyclonal Rabbit
  • IHC
  • WB
Abcam plc
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations