| ZFIN ID: ZDB-GENE-080424-6 |
| Gene Name: | myosin IXAb | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol: | myo9ab Nomenclature History |
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Attributions
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| Previous Names: | myo9a2 (1), myo9al2, im:7155152 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 25 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have several functions, including ATP binding activity; GTPase activator activity; and actin binding activity. Involved in axon extension and swimming behavior. Predicted to localize to several cellular components, including growth cone; myosin complex; and synapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:562199 (1), Ensembl(GRCz11):ENSDARG00000073843 (2) | |||||||||||||
| All Expression Data: | Fig. S2 from O'Connor et al., 2016 |
| Wild-type Stages, Structures: | Hatching:Long-pec (48.0h-60.0h) to Larval:Day 4 (96.0h-120.0h) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa16393 | Point Mutation | Unknown | Premature Stop | ENU |
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| sa24581 | Point Mutation | Unknown | Premature Stop | ENU |
|
| sa30171 | Point Mutation | Unknown | Premature Stop | ENU | |
| sa37972 | Point Mutation | Unknown | Premature Stop | ENU |
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| sa39467 | Point Mutation | Unknown | Premature Stop | ENU |
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| sa44210 | Point Mutation | Unknown | Splice Site | ENU |
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Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| CRISPR1-myo9ab |
|
1 |
| CRISPR2-myo9ab |
|
1 |
| MO1-myo9ab | N/A | 2 |
PHENOTYPE
| Data: | Fig. 1 from O'Connor et al., 2019 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Myasthenic syndrome, congenital, 24, presynaptic | 618198 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | axon development (more) |
| Cellular Component | cell junction (more) |
| Molecular Function | actin binding (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
myo9ab-203
(1)
|
7584 |
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|
|
| ncRNA | myo9ab-002 (1) | 497 |
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| Browsers: NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM myo9ab
No data available
MARKER RELATIONSHIPS
| myo9ab Contained in: | [Fosmid] CH1073-360M4 (1) |
| myo9ab Encodes: | [EST] IMAGE:7155152 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:XM_021470568 (1) |
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| Genomic | GenBank:CABZ01074930 (1) | 57974 nt | |
| Polypeptide | UniProtKB:E7F3F0 (1) | 2286 aa |
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ORTHOLOGY for myo9ab (
Chr:
25
)
CITATIONS (24)